Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC039
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-26 11:11
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 1/2+1/4+1/2+1/4 caps Madopar HBS 1 uvece Old patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 19 individuals with a value less than 0.57 were subsequently diagnosed with PD. That is, 45.24% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.57 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 5, 'TN': 5, 'TP': 37, 'FP': 25}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 41, 'TN': 29, 'TP': 1, 'FP': 1}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 39, 'TN': 29, 'TP': 3, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 5, 'TP': 37, 'FP': 25}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 22.588
timePerCircleCoV 0.190463
timePerCircleSlope -0.0208746
meanError 1.12073
tremorFreq 5.17578
tremorRelPower 38.938
tremorGyroAmpMean 0.0213802
tremorGyroAmpSlope -0.000498332
tremorGyroAmpCoV 0.351323
tremorCoordAmpMean 0.047855
tremorCoordAmpSlope 0.00334127
tremorCoordAmpCoV 2.04506
tremorAccAmpMean 0.0283518
tremorAccAmpSlope 0.000174957
tremorAccAmpCoV 0.276886
tremorPcRelVar 0.602939
tremorPcX 0.993761
tremorPcY -0.111535

Circle Segment 1

Duration 27.28 s, Accuracy Estimate 1.215 (lower is better)

Circle Segment 2

Duration 18.56 s, Accuracy Estimate 0.765 (lower is better)

Circle Segment 3

Duration 23.64 s, Accuracy Estimate 0.993 (lower is better)

Circle Segment 4

Duration 29.64 s, Accuracy Estimate 1.537 (lower is better)

Circle Segment 5

Duration 23.96 s, Accuracy Estimate 0.908 (lower is better)

Circle Segment 6

Duration 19.56 s, Accuracy Estimate 0.605 (lower is better)

Circle Segment 7

Duration 16.24 s, Accuracy Estimate 1.684 (lower is better)

Circle Segment 8

Duration 22.8 s, Accuracy Estimate 0.989 (lower is better)

Circle Segment 9

Duration 25.68 s, Accuracy Estimate 0.853 (lower is better)

Circle Segment 10

Duration 18.52 s, Accuracy Estimate 1.658 (lower is better)

Spiral

numSpirals 6
timePerSpiralMean 49.6067
timePerSpiralCoV 0.0860688
timePerSpiralSlope 0.0170254
meanError 2.02618
tremorFreq 6.05469
tremorRelPower 35.0697
tremorGyroAmpMean 0.0245206
tremorGyroAmpSlope -0.00144073
tremorGyroAmpCoV 0.431166
tremorCoordAmpMean 0.0449629
tremorCoordAmpSlope -0.000432164
tremorCoordAmpCoV 1.32764
tremorAccAmpMean 0.038193
tremorAccAmpSlope 0.000231407
tremorAccAmpCoV 0.282197
tremorPcRelVar 0.783202
tremorPcX -0.26609
tremorPcY -0.963948

Spiral Segment 1

Duration 50.68 s, Accuracy Estimate 1.709 (lower is better)

Spiral Segment 2

Duration 47.92 s, Accuracy Estimate 1.817 (lower is better)

Spiral Segment 3

Duration 46.84 s, Accuracy Estimate 2.316 (lower is better)

Spiral Segment 4

Duration 43.92 s, Accuracy Estimate 1.929 (lower is better)

Spiral Segment 5

Duration 55.88 s, Accuracy Estimate 1.882 (lower is better)

Spiral Segment 6

Duration 52.4 s, Accuracy Estimate 2.503 (lower is better)

Elel

eDurationMean 0.818375
eDurationStd 0.237312
eDurationStdnorm 0.28998
eDurationMedian 0.7525
eDurationQuartdelta 0.2075
eDurationQuartdeltanorm 0.275748
eDurationKurt 6.03456
eDurationTrenddiff 0.0975
eDurationTrendratio 1.13636
eWidthMean 5.22698
eWidthStd 1.03141
eWidthStdnorm 0.197324
eWidthMedian 5.148
eWidthQuartdelta 1.17
eWidthQuartdeltanorm 0.227273
eWidthKurt 6.03992
eWidthTrenddiff 0.4095
eWidthTrendratio 1.08434
eHeightMean 9.60862
eHeightStd 1.2809
eHeightStdnorm 0.133307
eHeightMedian 9.4185
eHeightQuartdelta 1.9305
eHeightQuartdeltanorm 0.204969
eHeightKurt 2.58647
eHeightTrenddiff 0.9945
eHeightTrendratio 1.10968
eAspectMean 0.54514
eAspectStd 0.078712
eAspectStdnorm 0.144389
eAspectMedian 0.546253
eAspectQuartdelta 0.0808877
eAspectQuartdeltanorm 0.148077
eAspectKurt 3.31468
eAspectTrenddiff -0.02195
eAspectTrendratio 0.960735
eSlantMean 0.303927
eSlantStd 0.105455
eSlantStdnorm 0.346976
eSlantMedian 0.294379
eSlantQuartdelta 0.108489
eSlantQuartdeltanorm 0.368534
eSlantKurt 3.11477
eSlantTrenddiff -0.0717316
eRtopMean 0.917634
eRtopStd 0.0506327
eRtopStdnorm 0.0551774
eRtopMedian 0.910101
eRtopQuartdelta 0.0632834
eRtopQuartdeltanorm 0.0695344
eRtopKurt 3.75331
eRtopTrenddiff -0.0466212
eRbotMean 0.363398
eRbotStd 0.131046
eRbotStdnorm 0.360612
eRbotMedian 0.330729
eRbotQuartdelta 0.141402
eRbotQuartdeltanorm 0.427547
eRbotKurt 4.92589
eRbotTrenddiff 0.0656419
eRrightMean 0.947577
eRrightStd 0.029891
eRrightStdnorm 0.0315447
eRrightMedian 0.947657
eRrightQuartdelta 0.0457683
eRrightQuartdeltanorm 0.0482963
eRrightKurt 2.17873
eRrightTrenddiff -0.00875682
eRleftMean 0.165656
eRleftStd 0.0622233
eRleftStdnorm 0.375617
eRleftMedian 0.16954
eRleftQuartdelta 0.0798403
eRleftQuartdeltanorm 0.470923
eRleftKurt 2.94634
eRleftTrenddiff 0.0307595
lDurationMean 0.9275
lDurationStd 0.133491
lDurationStdnorm 0.143926
lDurationMedian 0.895
lDurationQuartdelta 0.16
lDurationQuartdeltanorm 0.178771
lDurationKurt 3.73001
lDurationTrenddiff 0.08
lDurationTrendratio 1.09249
lWidthMean 9.51087
lWidthStd 1.44424
lWidthStdnorm 0.151852
lWidthMedian 9.477
lWidthQuartdelta 2.223
lWidthQuartdeltanorm 0.234568
lWidthKurt 2.61941
lWidthTrenddiff 0.936
lWidthTrendratio 1.1039
lHeightMean 18.8893
lHeightStd 1.97822
lHeightStdnorm 0.104727
lHeightMedian 18.8955
lHeightQuartdelta 2.106
lHeightQuartdeltanorm 0.111455
lHeightKurt 2.68674
lHeightTrenddiff 0.936
lHeightTrendratio 1.05096
lAspectMean 0.502579
lAspectStd 0.0454176
lAspectStdnorm 0.0903691
lAspectMedian 0.507309
lAspectQuartdelta 0.0519601
lAspectQuartdeltanorm 0.102423
lAspectKurt 2.79229
lAspectTrenddiff 0.00115447
lAspectTrendratio 1.00228
lSlantMean 0.349338
lSlantStd 0.0638087
lSlantStdnorm 0.182656
lSlantMedian 0.345886
lSlantQuartdelta 0.0777888
lSlantQuartdeltanorm 0.224897
lSlantKurt 2.7829
lSlantTrenddiff -0.0288478
lRtopMean 0.944232
lRtopStd 0.0372783
lRtopStdnorm 0.03948
lRtopMedian 0.950617
lRtopQuartdelta 0.0375296
lRtopQuartdeltanorm 0.0394791
lRtopKurt 2.75854
lRtopTrenddiff -0.000602228
lRbotMean 0.251807
lRbotStd 0.08027
lRbotStdnorm 0.318776
lRbotMedian 0.241742
lRbotQuartdelta 0.12044
lRbotQuartdeltanorm 0.498216
lRbotKurt 2.46121
lRbotTrenddiff 0.0605464
lRrightMean 0.959737
lRrightStd 0.0272857
lRrightStdnorm 0.0284303
lRrightMedian 0.964445
lRrightQuartdelta 0.0350497
lRrightQuartdeltanorm 0.0363419
lRrightKurt 4.5675
lRrightTrenddiff 0.00519905
lRleftMean 0.113894
lRleftStd 0.0505068
lRleftStdnorm 0.443455
lRleftMedian 0.103825
lRleftQuartdelta 0.0496379
lRleftQuartdeltanorm 0.478091
lRleftKurt 3.05728
lRleftTrenddiff 0.00922155

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.9375
sumTouchScores 15
meanMovementTime 1.09367
numTouches 16
undershootPercentage 0
overshootPercentage 6.25

FITTS Long Modified

meanTouchScore 0.922299
sumTouchScores 12.9122
meanMovementTime 1.36615
numTouches 14
undershootPercentage 0
overshootPercentage 14.2857

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 48.784
timePerZigzagCoV 0.130647
timePerZigzagSlope -0.0671532
meanError 2.33519
tremorFreq 5.95703
tremorRelPower 36.7638
tremorGyroAmpMean 0.0276409
tremorGyroAmpSlope 0.000782804
tremorGyroAmpCoV 0.373635
tremorCoordAmpMean 0.0453283
tremorCoordAmpSlope 0.000416112
tremorCoordAmpCoV 0.505968
tremorAccAmpMean 0.0339173
tremorAccAmpSlope 0.00035429
tremorAccAmpCoV 0.365899
tremorPcRelVar 0.775805
tremorPcX -0.166114
tremorPcY 0.986107

ZigZag Segment 1

Duration 59.64 s, Accuracy Estimate 2.004 (lower is better)

ZigZag Segment 2

Duration 47.68 s, Accuracy Estimate 2.23 (lower is better)

ZigZag Segment 3

Duration 45.52 s, Accuracy Estimate 2.551 (lower is better)

ZigZag Segment 4

Duration 47.96 s, Accuracy Estimate 2.46 (lower is better)

ZigZag Segment 5

Duration 43.12 s, Accuracy Estimate 2.432 (lower is better)

ZigZag Offset

numZigzags 4
timePerZigzagMean 37.51
timePerZigzagCoV 0.11923
timePerZigzagSlope -0.0446814
zigzagHeightMean 58.9892
zigzagHeightCoV 0.0772872
zigzagHeightSlope -0.0498537
meanError 0.0432834
tremorFreq 6.25
tremorRelPower 38.0424
tremorGyroAmpMean 0.0173729
tremorGyroAmpSlope 0.00102123
tremorGyroAmpCoV 0.372564
tremorCoordAmpMean 0.0537093
tremorCoordAmpSlope -0.00136001
tremorCoordAmpCoV 0.81587
tremorAccAmpMean 0.0752582
tremorAccAmpSlope 0.00010832
tremorAccAmpCoV 0.0606599
tremorPcRelVar 0.819397
tremorPcX -0.153144
tremorPcY -0.988204

ZigZag Offset Segment 1

Duration 37.08 s, Accuracy Estimate 0.055 (lower is better)

ZigZag Offset Segment 2

Duration 43.96 s, Accuracy Estimate 0.039 (lower is better)

ZigZag Offset Segment 3

Duration 34.28 s, Accuracy Estimate 0.038 (lower is better)

ZigZag Offset Segment 4

Duration 34.72 s, Accuracy Estimate 0.041 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.6}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.57}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.018842464609706955}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.6754180258971763}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.6864638299216052}